CBD and Endocannabinoid System


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CBD or cannabidiol is a promising phytocannabinoid that works within the endocannabinoid system.  Agricultural hemp contains the CBD .  It has been recognized for its benefits on human and animal health because it is capable of affecting nearly every biological process.

The History of Cannabis

Cannabis has been around for a long, long time.  Western medicine was introduced to cannabis in the 1840s.  Despite the current use and status of cannabis in the United States, cannabis was the medicine of choice in the early 1900s because it was promoted as having analgesic, sedative, anti-inflammatory, antispasmodic, and anticonvulsant properties.

Become Familiar with the Terminology

Cannabis Sativa L is the source of medical cannabis and agricultural hemp.  Cannabis Sativa L. contains over 120 cannabinoids, including CBD.

Medical Cannabis is cannabis for medical purposes.

Agricultural or Industrial Hemp is less than 0.3% TCH by dry weight.  This hemp uses the whole plant which has added benefits.

The Endocannabinoid System

In the mid 1900s, we learned that we have our own endocannabinoid system.  In addition, we learned that we have our own cannabis like compounds inside of our body naturally.  The endocannabinoid receptor was first discovered in 1992.  Since that time, scientists and researchers have been studying the central regulatory system called the endocannabinoid system or the ECS.  Naturally occurring cannabis-like compounds and enzymes influence this system.  The ECS or endocannabinoid system is a very important system.  The endocannabinoid system is responsible for creating and maintaining homeostasis within the body.

The body contains endocannabinoids and receptors everywhere.  In addition, every organ system contains these receptors.  In different tissues and different parts of the body, cannabinoids perform different tasks.  Despite this, the goal of the cannabinoids is always the same: homeostasis.  Homeostasis is maintaining a stable internal environment despite fluctuations in the external environment.

Especially relevant is how the endocannabinoid system is involved in the direct regulation of appetite, metabolic health, pain/inflammation, thermoregulation, intraocular pressure, sensation, muscle control, motivation/reward, mood and memory.  In addition, the endocannabinoid system is involved in learning and synaptic plasticity.

Maintaining Endocannabinoid System Tone

The CB1 receptor within the endocannabinoid system is responsible for decreasing anxiety, reducing pain, decreasing inflammation, controlling sensory perception, memory and cognitive function.  Opposite this, a diet filled with toxins and processed foods along with stress will overstimulate the CB1 receptor.  As a result of this over stimulation, the body has bad side effects: anxiety, inflammation, insulin resistance, poor sleep, etc.

CBD Oil Working Inside the Endocannabinoid System

CBD oil is a phytocannabinoid that can mimic endocannabinoids.  This allows the CBD oil to modulate the tone of the endocannabinoid system.  Modulating the tone of the ECS promotes homeostasis inside the body.  The ECS is essential to life.

The Cannabis Sativa L plant contains the CBD.  Because of this, CBD oil belongs to a class of molecules called cannabinoids.  CBD oil is a legal dietary supplement.  In addition, nutrient rich hemp contains excellent nutritional value and essential fatty acids.  Lastly, CBD oil is not psycho active; it will not get you high.  Inside the endocannabinoid system, CBD balances the consistent over stimulation of the CB1 receptor.  Cannabidiol or CBD helps balance the system that keeps you balanced.

CBD Safety

Studies show that CBD is non-toxic.  In addition, chronic use and high doses up to 1500mg per day of CBD are reportedly well tolerated in humans.  Nor does CBD use affect GI transit nor alter psychomotor or psycholgic functions.

Where is the research?

Cannabis is a schedule 1 drug.  Hence, it is very difficult to conduct research.  By definition, schedule 1 means that there is no potential for medical benefit and highly addictive.  When a drug is listed as schedule 1, you are limited to the amount of research that can be done on humans.  There is no reference of CBD in the federal acts.  Furthermore, CBD is not directly scheduled.  Also, hemp is not defined as “marijuana” under the Controlled Substance Act.  Lastly, Agricultural hemp fiber, stalk seed and oils can be lawfully imported into the United States and these portions of the hemp plant may enter into US commerce.

CBD vs Medical Cannabis

  • CBD

    • Non psychoactive
    • Does not result in feelings of euphoria
    • Does not cause intoxification
    • CBD contains trace amounts of THC (less than 0.3%)
    • Legal
  • Medical Cannabis

    • Associated with the feeling of being high
    • Results in euphoria and psycoactivity
    • Contains 5-10% THC
    • Illegal in most states
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Forms of CBD Oil

Drops or Sprays

These are the most popular.  Since they can put put under the tongue, they often work faster than other dosage forms.  Some patients even say they notice a difference almost immediately.  Package size is also convenient; the bottles are small enough that they can easily fit into a purse for easy transport.  If you are first starting out and are new to cannabidiol, this is the dosage form you should start with.  The effects that cannabidiol has on someone is unique to that individual.  The dosage that works for you may not work for someone else and vice versa.  Hence, when starting out you need to be able to adjust your dosage on a daily basis easily.  Once you find the dosage that makes you healthy, you can than change dosage forms if you desire.  Lastly, they taste great.  If you like Peppermint Patties, you’ll like these.

CBD and Endocannabinoid System
CBD drops and sprays are a very popular dosage form.


Capsules are a popular dosage form in America. The capsules are an excellent dosage form for patients who want to use cannabidiol oil daily.  In addition, the capsules may have a prolonged effect on a person.  This is because the outer shell of the capsule has to dissolve in the stomach and GI tract.  Hence, this provides a different experience for patients.  Finally, if you would like to hear a patient discuss her experience using the capsules, watch this video.


Another easy and convenient way to take cannabidiol daily.  These softgels are ideal for patients who don’t like to swallow pills.  In addition, these are great for patients who want a fast acting CBD oil supplement.  These soft gels represent a compelling solution.  The soft gels work quickly because they dissolve quickly.

CBD Oil Softgels


All of the concentrates deliver cannabinoids, naturally occurring vitamin E and fatty acids, and are available in a highly concentrated, purified and tested from.  The Gold Formula and the Total Plant Complex Concentrates are for the purists.  Hence, these products deliver the purest and most consistent CBD oil of any other brand.  Since these are pure and concentrated, these are for experienced cannabinoid users.  The patients who use these products know how much they want to take.  In addition, these patients have generally found the quantity that works best for them.

CBD Oil Concentrates


Balms go on your skin.  Plus CBD Balm offers skin care from the highest quality line of non-GMO CBD oil products on the market.  This balm will give your skin what it craves to feel fresh and supple.  These contain CBDA and CBD.  Because of this, they revitalize your skin.  Balms leave your skin feeling moisturized and supple.  Balms can have a fresh, cool sensation.

CBD Oil Balm

Plus CBD Oil

We believe that this company makes the highest quality cannabinoid products on the market.  This company believes that it is imperative to be a part of every step of the supply chain process.  This is why, from harvesting their hemp seeds to laboratory testing for quality to distributing their exception finished products, they are committed to going the extra mile.

Plus CBD Oil has exclusive contracts with local farmers in Europe to use EU- certified hemp seeds.  In addition, they use an on-site European ISO-certified facility to perform CO2 extraction.  As you can imagine, testing is of the utmost importance.  This company tests for cannabinoid content of their products.  Furthermore, Plus CBD Oil tests for contaminants, heavy metals and solvents.  Lastly, they send their oil to a third party laboratory to verify concentration, quality and safety.  There is great value in this.

Through a proprietary chemical-free process, this company converts their raw CO2 extracted oil into varying concentrations of their hemp-derived cannabidiol oil.  Their oil is formulated and bottled at a GMP and NSF-certified facility.  Lastly, from Seed to Shelf, they guarantee the highest quality hemp-derived CBD oil products.